Features of expression of somatostatin receptors in gastric carcinomas depending on the proportion of the neuroendocrine component

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2021-67-5-683-686

Published 29.10.2021

Oleg Kit⁺⁻
Irina Derizhanova⁺⁻
Nikolay Karnaukhov⁺⁻
Inna Novikova⁺⁻
Vladimir Trifanov⁺⁻
Gennadiy Kaminsky⁺⁻

Oleg Kit

National Medical Research Centre for Oncology

Irina Derizhanova

Rostov State Medical University

Nikolay Karnaukhov

Moscow Clinical Scientific Center n.a. A.S. Loginov

Inna Novikova

National Medical Research Centre for Oncology

Vladimir Trifanov

National Medical Research Centre for Oncology

Gennadiy Kaminsky

National Medical Research Centre for Oncology

pdf (Русский)

Keywords

gastric cancer
neuroendocrine tumors
somatostatin receptors

How to Cite

Kit, O., Derizhanova, I., Karnaukhov, N., Novikova, I., Trifanov, V., & Kaminsky, G. (2021). Features of expression of somatostatin receptors in gastric carcinomas depending on the proportion of the neuroendocrine component. Voprosy Onkologii, 67(5), 683–686. https://doi.org/10.37469/0507-3758-2021-67-5-683-686

Abstract

In 50 patients with gastric cancer, a neuroendocrine component was screened using immunohistochemical studies with antibodies to chromogenic and synaptophysin in the surgical material, as well as a somatostatin receptor status researcher (SSTR). The neuroendocrine component in various proportions was found in 62% of observers. In 2 neuroendocrine carcinomas, expression of type 2 SSTR was observed at the level of “2+”, and only one adeno-neuroendocrine carcinoma produced the same expression. In carcinomas with and without neuroendocrine component, the expression of various types of SSTR was detected in 61.8% of observers in both neuroendocrine and exocrine structures. In the group of highly differentiated neuroendocrine tumors, 100% of the observers detected the expression of at least one of the 5 types of somatostatin receptors, and in 95% - at the «3+» level. The data obtained do not allow making statistically significant conclusions about the dependence of the expression of SSTR on the presence of the neuroendocrine component, but with the prospect of further study not only in neuroendocrine tumors, but also in exocrine and mixed carcinomas.

https://doi.org/10.37469/0507-3758-2021-67-5-683-686

pdf (Русский)

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