Vol. 69 No. 2 (2023), REVIEWS

Vol. 69 No. 2 (2023)

Myocarditis associated with immune checkpoint inhibitor therapies: diagnostic and treatment strategies

REVIEWS

https://doi.org/10.37469/0507-3758-2023-69-2-219-226

Published 30.04.2023

Marina Balliuzek⁺⁻
Svetlana Protsenko
Vera Potiyevskaya

Marina Balliuzek

СПб больница РАН

https://orcid.org/0000-0003-3223-0241

Svetlana Protsenko

https://orcid.org/0000-0002-4636-4200

Vera Potiyevskaya

pdf (Русский)

Keywords

immune checkpoint inhibitors
myocarditis
cardiotoxicity
cardiovascular immune-related adverse events
review

How to Cite

Balliuzek, M., Protsenko, S., & Potiyevskaya , V. (2023). Myocarditis associated with immune checkpoint inhibitor therapies: diagnostic and treatment strategies. Voprosy Onkologii, 69(2), 219–226. https://doi.org/10.37469/0507-3758-2023-69-2-219-226

Abstract

This review aims to provide information on myocarditis and inflammatory cardiomyopathies associated with immune checkpoint inhibitor (ICI) therapies. Additionally, it will present current data on strategies for diagnosis and treatment of these conditions. As immunotherapy becomes more widely used, it has revealed diverse clinical symptoms, courses, and outcomes of cardiovascular immune-related adverse events (irAEs). These range from rare but potentially life-threatening fulminant forms to mild symptomatic courses that can lead to the development of dilated cardiomyopathy, arrhythmias, and heart failure. The review discusses the risk factors and common comorbid clinical conditions of irAE-associated myocarditis, as well as severity assessment and observation algorithms. The importance of a multidisciplinary approach to managing patients with this cardiotoxic irAE is also emphasized.

https://doi.org/10.37469/0507-3758-2023-69-2-219-226

pdf (Русский)

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