Abstract
With the use of regression and dispersion analyzes conducted in this study it was possible to identify predictive factors that significantly worsen the prognosis of Hodgkin’s lymphoma in adolescents however constructed regression equations did not pass the quality assessment of the models, which did not allow them to be used for the construction of point and interval predictions. In a cohort of patients enrolled in the study a risk-adapted treatment program based on the risk group for stratification was conducted. Negative aspects of the results of our study could be related to the already selected volume of the program for these patients. In turn our analysis proves the validity of the selection of therapeutic loads (a number of cycles of polychemotherapy, doses of radiation therapy) depending on the risk group, into which the adolescent is stratified.References
Колыгин Б.А., Кулева С.А. Диагностика и лечение лимфомы Ходжкина. - СПб.: Гиппократ, 2009. - 208 с.
Юнкеров В.И., Григорьев С.Г, Резванцев М.В. Математико-статистическая обработка данных медицинских исследований. - СПб: ВМедА, 2002. - 266 с.
Bleyer A., O'Leary M., Barr R., Ries L. Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, Including SEER Incidence and Survival: 1975-2000 // National Cancer Institute, NIH Pub. No. 06-5767. Bethesda, MD. - 2006. - 218 p.
Donaldson S.S., Hudson M.M., Lamborn K. et al. VAMP and low-dose, involved-field radiation for children and adolescents with favorable, early-stage Hodgkin's disease: results of prospective clinical trial // J. Cln. Oncol. - 2002. - Vol. 20. - P. 3081-3087.
Dorffel W., Ruhl U., Luders H. et al. Treatment of children and adolescents with Hodgkin lymphoma without radiotherapy for patients in complete remission after chemotherapy: final results of the multinational trial GPOH-HD95 // J. Clin. Oncol. - 2013. - Vol. 20. - 31(12). - P. 1562-1568.
Herbertson R.A., Evans L.S., Hutchinson J. et al. Poor outcome in adolescents with high-risk Hodgkin lymphoma // Int. J. Oncol. - 2008. - Vol. 33. - № 1. - P. 145-151.
Kulyova S., Kolygin B. Hodgkin's lymphoma in children and adolescents: a Saint Petersburg Hodgkin's Lymphoma Group Study // J. Oncol. - 2011. -http://dx.doi. org/. DOI: 10.1155/2011/958435
Landman-Parker J., Pacquement H., Leblanc T et al. Localized childhood Hodgkin's disease: response-adapted chemotherapy with etoposide, bleomycin, vinblastine, and prednisone before low-dose radiation therapy - results of the French Society of Pediatric Oncology Study MDH90 // J. Clin. Oncol. - 2000. - Vol. 18. - № 7. - P. 1500-1507.
Schellong G., Potter R., Bramswig J.H. et al. High cure rates and reduced long-term toxicity in pediatric Hodgkin's disease: the German-Austrian Multicenter Trial DAL-HD-90 // J. Clin. Oncol. - 1999. - Vol. 17. - № 12. - P. 3736-3744.
Schellong G. The balance between cure and late effects in childhood Hodgkin's lymphoma: the experience of the German-Austrian Study-Group since 1978 // Ann. Oncol. - 1996. - Vol. 7. - № 4. - P. 67-72.
Yung L., Smith P., Hancock B.W. et al. Long-term outcome in adolescents with Hodgkin lymphoma: poor results using regimens designed for adults // Leuk. Lymphoma. -2004. - Vol. 45. - P. 1579-1585.
Zweig M.H., Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine // Clin. Chemistry. - 1993. - Vol. 39. - P. 561-577.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© АННМО «Вопросы онкологии», Copyright (c) 2017