Vol. 64 No. 1 (2018), ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Vol. 64 No. 1 (2018)

OVARIAN CYSTS AND HYPERESTROGENIA AS A SIDE EFFECT OF TAMOXIFEN THERAPY IN BREAST CANCER PATIENTS OF REPRODUCTIVE AND POSTMENOPAUSAL AGE

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-1-88-94

Published 01.01.2018

Yevgeniya Tsyrlina⁺⁻
Yelena Zhiltsova⁺⁻
Tatyana Poroshina⁺⁻
Irina Meshkova⁺⁻
Lev Bershteyn⁺⁻
Vladimir Semiglazov⁺⁻
N. Barash⁺⁻

Yevgeniya Tsyrlina

N.N. Petrov National Medical Research Center of Oncology

Yelena Zhiltsova

N.N. Petrov National Medical Research Center of Oncology

Tatyana Poroshina

N.N. Petrov National Medical Research Center of Oncology

Irina Meshkova

N.N. Petrov National Medical Research Center of Oncology

Lev Bershteyn

N.N. Petrov National Medical Research Center of Oncology

Vladimir Semiglazov

N.N. Petrov National Medical Research Center of Oncology

N. Barash

N.N. Petrov National Medical Research Center of Oncology

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Keywords

BREAST CANCER
TAMOXIFEN
OVARIAN CYSTS
ESTRADIOL

How to Cite

Tsyrlina, Y., Zhiltsova, Y., Poroshina, T., Meshkova, I., Bershteyn, L., Semiglazov, V., & Barash, N. (2018). OVARIAN CYSTS AND HYPERESTROGENIA AS A SIDE EFFECT OF TAMOXIFEN THERAPY IN BREAST CANCER PATIENTS OF REPRODUCTIVE AND POSTMENOPAUSAL AGE. Voprosy Onkologii, 64(1), 88–94. https://doi.org/10.37469/0507-3758-2018-64-1-88-94

Abstract

The paper presents the results of a survey of 254 patients of reproductive and menopausal age who after the completion of the surgical, in some patients also chemo-radiotherapY., received tamoxifen for breast cancer for different lengths of time. All patients underwent ultrasound examination of pelvic organs and determination of the content of estradiol, follicle-stimulating and luteinizing hormones in the serum. It was showed that with tamoxifen therapy ovarian cysts were diagnosed in 50 women with preserved menstrual cycle (73.5%) and 31 - in menopause (16.6%). Detection of cysts in 72% of patients of reproductive age and 19.3% of menopausal age was accompanied by increased production of estradiol. Cyst formation and hyperproduction of estradiol appeared mainly during the first year of tamoxifen; in the future they could disappear, which made it possible to observe such patients and not immediately made a decision about the need for pharmacological or surgical suppression of ovarian function.

https://doi.org/10.37469/0507-3758-2018-64-1-88-94

##article.numberofdownloads## 518

##article.numberofviews## 2177

PDF (Русский)

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