DETECTION OF RESIDUAL LUNG CANCER CELLS BY PCR-BASED GENETIC TESTING FOR ROS1-TRANSLOCATION: CASE REPORT

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2018-64-3-331-334

Published 01.03.2018

Fedor Moiseenko⁺⁻
Vladislav Tyurin⁺⁻
Nikita Levchenko⁺⁻
Yevgeniy Levchenko⁺⁻
Aglaya Ievleva⁺⁻
Yevgeniy Imyanitov⁺⁻
Natalya Mityushkina⁺⁻

Fedor Moiseenko

St. Petersburg Clinical Scientific and Practical Center of Specialized Medical Care (Oncology), I.I. Mechnikov North-West State Medical University

Vladislav Tyurin

N.N. Petrov National Medical Research Center of Oncology

Nikita Levchenko

N.N. Petrov National Medical Research Center of Oncology

Yevgeniy Levchenko

I.I. Mechnikov North-West State Medical University, N.N. Petrov National Medical Research Center of Oncology

Aglaya Ievleva

N.N. Petrov National Medical Research Center of Oncology, St. Petersburg State Pediatric Medical University

Yevgeniy Imyanitov

I.I. Mechnikov North-West State Medical University, N.N. Petrov National Medical Research Center of Oncology, St. Petersburg State Pediatric Medical University

Natalya Mityushkina

N.N. Petrov National Medical Research Center of Oncology

PDF (Русский)

Keywords

LUNG CANCER
ТРАНСЛОКАЦИЯ ROS1
ROS1-TRANSLOCATION
CRIZOTINIB

How to Cite

Moiseenko, F., Tyurin, V., Levchenko, N., Levchenko, Y., Ievleva, A., Imyanitov, Y., & Mityushkina, N. (2018). DETECTION OF RESIDUAL LUNG CANCER CELLS BY PCR-BASED GENETIC TESTING FOR ROS1-TRANSLOCATION: CASE REPORT. Voprosy Onkologii, 64(3), 331–334. https://doi.org/10.37469/0507-3758-2018-64-3-331-334

Abstract

A patient with lung cancer carrying ROS1 translocation was treated by crizotinib and then subjected to surgery. Morphological analysis revealed pathologic complete response in surgically removed tissues, while PCR test provided convincing evidence for the presence of residual tumor cells. PCR analysis of lung cancer specific gene translocations allows carrying out highly sensitive and reliable monitoring of tumor disease during the course of treatment.

https://doi.org/10.37469/0507-3758-2018-64-3-331-334

PDF (Русский)

References

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