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Abstract
Struma ovarii is a rare variant of the mature ovarian teratoma composed of more than 50% thyroid tissue. Thyroid type carcinoma can occur in 5% of struma ovarii. Given the rarity of this pathology, as well as the different clinical course, approaches to the treatment of this disease are controversial. The proposed approaches to treatment vary from ovarian resection to total hysterectomy with bilateral salpingo-oophorectomy and adjuvant therapy. We present here 6 case reports of thyroid type carcinoma in struma ovarii and outcome of patients treated in our clinic. All patients had pelvic surgery of different extent, followed by thyroidectomy and radioiodine therapy. The incidence of metastasis is 67% (4/6), 2 - intraperitoneal metas-tases, 2 - bone metastases. Among patients with metastases, 2 have reached a complete response, one with a good response continues treatment, one had progression. The follow-up period is 1 to 15 years (median 4 years). One patient with follicular carcinoma died of progression 8 years after diagnosis. The remaining patients are alive.References
Zhang X., Axiotis C. Thyroid-type carcinoma of struma ovarii // Arch Pathol. Lab. Med. -2010. - Vol. 134(5). -P. 786-791. - DOI: 10.1043/1543-2165-134.5.786
Prat J., Cao D., Carinelli S.G., Nogales F.F. et al. Monodermal teratomas and somatic-type tumors arising in a dermoid cyst / In: Kurman R.J., Carcangiu M.L., Herrington S., and Young R.H., editors. WHO Classification of Tumors of Female Reproductive Organs. - IARC, Lyon, France, 2014. - P. 63-66.
Roth L.M., Talerman A. Recent advances in the pathology and classification of ovarian germ cell tumors // Int J. Gynecol. Pathol. - 2006. - Vol. 25 (4). - P. 305-320. - DOI: 10.1097/01.pgp.0000225844.59621.9d
Boettlin R. Uber Zahnentwickelung in Dermoidcysten des Ovariums // Virch Arch [Pathol Anat]. - 1889. - Vol. 115. - P. 493-504.
Piana S., Damiani S., Santini D. Oxyphilic follicular tumor arising in struma ovarii // Tumori. -1994. - Vol. 80. - P. 482-484.
Roth L.M., Karseladze A.I. Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis // Int. J. Gynecol. Pathol. - 2008. - Vol. 27(2). - P. 213-222. -DOI: 10.1097/PGP.0b013e318158e958
Wei S., Baloch Z.W., LiVolsi V.A. Pathology of Struma Ovarii: A Report of 96 Cases // Endocr Pathol. - 2015. - Vol. 26(4). - P. 342-348. - DOI: 10.1007/s12022-015-9396-1
Shaco-Levy R., Peng R.Y, Snyder M.J. et al. Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior // Arch Pathol. Lab Med. - 2012. - Vol. 136(2). - P. 172-178. - DOI: 10.5858/arpa.2011-0092-OA
Fukunaga M., Ishibashi T., Koyama T. et al. Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma // Int. J. Gynecol. Pathol. - 2016. - Vol. 35(4). - P. 357-361. - DOI: 10.1097/PGP.0000000000000265
Khunamornpong S., Settakorn J., Sukpan K. et al. Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii // Case Rep Pathol. - 2015. - Vol. 2015. - P. 826978. - DOI: 10.1155/2015/826978
Williams H., Salinas E., Savage E. et al. Malignant struma ovarii with insular carcinoma: A case report and literature review // Gynecol. Oncol. Rep. - 2016. - Vol. 18. - P. 1-3. - DOI: 10.1016/j.gore.2016.08.003
Shamanna R.K., Lee M.W., Gaba A.R. Struma ovarii with a focus of medullary thyroid carcinoma [poster 24] // Arch Pathol. Lab Med. - 2008. - Vol. 132(9). - P. 1510.
Mardi K., Gupta N. Tall cell variant of papillary carcinoma arising from struma ovarii: A rare case report // J. Can Res. Ther. - 2013. - Vol. 9. - P. 119-121.
Lara C., Cuenca D., Salame L. et al. A Hormonally Active Malignant Struma Ovarii // Case Rep Oncol. Med. - 2016. - Vol. 2016. - P. 2643470.
Goffredo P., Sawka A.M., Pura J. et al. Malignant struma ovarii: a population-level analysis of a large series of 68 patients // Thyroid. - 2015. - Vol. 25(2). - P. 211-215. - DOI: 10.1089/thy.2014.0328
Robboy S.J., Shaco-Levy R., Peng R.Y. et al. Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread // Int. J. Gynecol. Pathol. - 2009. - Vol. 28(5). - P. 405-422. - DOI: 10.1097/PGP.0b013e3181a27777
Makani S., Kim W, Gaba AR. Struma Ovarii with a focus of papillary thyroid cancer: a case report and review of the literature // Gynecol. Oncol. - 2004. - Vol. 94(3). - P. 835-839.
Jean S., Tanyi J.L., Montone K. et al. Papillary thyroid cancer arising in struma ovarii // J. Obstet. Gynaecol. - 2012. - Vol. 32(3). - P. 222-226. - DOI: 10.3109/014436
Marcy P.Y, Thariat J., Benisvy D., Azuar P. Lethal, malignant, metastatic struma ovarii // Thyroid. - 2010. -Vol. 20(9). - P. 1037-1040. - DOI: 10.1089/thy.2010.0022
Yassa L., Sadow P., Marqusee E. Malignant struma ovarii // Nat. Clin. Pract. Endocrinol. Metab. - 2008. - Vol. 4(8). - P. 469-472. - DOI: 10.1038/ncpendmet0887
Roth L.M., Miller A.W. 3rd, Talerman A. Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature // Int. J. Gynecol. Pathol. - 2008. - Vol. 27(4). - P. 496-506. - DOI: 10.1097/PGP.0b013e31816a74c6
DeSimone C.P., Lele S.M., Modesitt S.C. Malignant struma ovarii: a case report and analysis of cases reported in the literature with focus on survival and I131 therapy // Gynecol. Oncol. -2003. - Vol. 89(3). - P. 543-548.
Marti J.L., Clark V.E., Harper H. et al. Optimal surgical management of well-differentiated Thyroid cancer arising in struma ovarii: a series of 4 patients and a review of 53 reported cases // Thyroid. - 2012. - Vol. 22(4). - P. 400-406. - DOI: 10.1089/thy.2011.0162
Brusca N., Del Duca S.C., Salvatori R. et al. A case report of thyroid carcinoma confined to ovary and concurrently occult in the thyroid: is conservative treatment always advised? // Int. J. Endocrinol. Metab. - 2015. - Vol. 22. - P. 13(1):e18220. - DOI: 10.5812/ijem.18220
Corrado G., Pomati G., Russo A. et al. Ovarian metastasis from thyroid carcinoma: a case report and literature review // Diagn Pathol. - 2014. - Vol. 9 (1). - P. 193. - DOI: 10.1186/s13000-014-0193-9
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