EFFICIENCY OF ADJUVANT XELOX CHEMOTHERAPY FOR PATIENTS WITH RESECTABLE GASTRIC IN RUSSIA (SINGLE INSTITUTION RETROSPECTIVE STUDY)

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2019-65-2-256-262

Published 01.02.2019

Ivan Stilidi⁺⁻
Sergey Nered⁺⁻
Aleksey Kalinin⁺⁻
Olesya Rossomakhina⁺⁻
Anton Barchuk⁺⁻

Ivan Stilidi

Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation

Sergey Nered

Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation

Aleksey Kalinin

Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation

Olesya Rossomakhina

State Institution “St. Luka Lugansk State Medical University “

Anton Barchuk

"Federal State Budgetary Institution «N.N. Petrov National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation

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Keywords

XELOX
ADJUVANT CHEMOTHERAPY
GASTRIC CANCER
SUBTOTAL GASTRECTOMY
TOTAL GASTRECTOMY

How to Cite

Stilidi, I., Nered, S., Kalinin, A., Rossomakhina, O., & Barchuk, A. (2019). EFFICIENCY OF ADJUVANT XELOX CHEMOTHERAPY FOR PATIENTS WITH RESECTABLE GASTRIC IN RUSSIA (SINGLE INSTITUTION RETROSPECTIVE STUDY). Voprosy Onkologii, 65(2), 256–262. https://doi.org/10.37469/0507-3758-2019-65-2-256-262

Abstract

Introduction. The effectiveness of the Asian regimen of adjuvant chemotherapy in patients with gastric cancer in the European population remains unclear. The aim of our study was a retrospective assessment of adjuvant chemotherapy (XELOX regimen) after radical surgery (R0) on overall survival. Methods. Database of pts with resectable gastric cancer with stage >pT3 and/or pN+ and M0, who were operated (R0) at single oncological institution during 2007-2017 was reviewed. In univariate and multivariate analyzes were included demographic characteristics, type of tumor according to Lauren, stage, type of treatment and others. Results. 396 pts were identified and 286 were available for analysis.106 (37%) pts received at least one cycle of adjuvant chemotherapy. In univariate analysis, 5OS rate was 64% [95% Cl, 52-80] и 56% [95% Cl, 48-64; p=0,21] in patients received adjuvant chemotherapy and only surgical treatment. After stratifying patients depending on the regional lymph nodes metastasis, 5OS rate in pts with pN1-3 was 69% [95% CI, 57-85] vs 47% [95% CI, 39-58; p = 0,01], respectively...

https://doi.org/10.37469/0507-3758-2019-65-2-256-262

##article.numberofdownloads## 407

##article.numberofviews## 1083

PDF (Русский)

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