IMPACT OF PREOPERATIVE THERMOCHEMORADIOTHERAPY ON SURGICAL OUTCOMES IN PATIENTS WITH NON-SMALL CELL LUNG CANCER

ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

https://doi.org/10.37469/0507-3758-2020-66-2-143-147

Published 01.02.2020

Aleksey Dobrodeev⁺⁻
Sergey Tuzikov⁺⁻
Aleksandr Zavyalov⁺⁻
Zhanna Startseva⁺⁻

Aleksey Dobrodeev

Tomsk National Research Medical Center Russian Academy of Sciences

Sergey Tuzikov

Tomsk National Research Medical Center Russian Academy of Sciences

Aleksandr Zavyalov

Research Institute of Health Organization and Medical Management of the Moscow Department of Health

Zhanna Startseva

Tomsk National Research Medical Center Russian Academy of Sciences

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Keywords

NON-SMALL CELL LUNG CANCER
SURGICAL TREATMENT
CHEMORADIOTHERAPY
LOCAL HYPERTHERMIA
POSTOPERATIVE COMPLICATIONS
MORTALITY

How to Cite

Dobrodeev, A., Tuzikov, S., Zavyalov, A., & Startseva, Z. (2020). IMPACT OF PREOPERATIVE THERMOCHEMORADIOTHERAPY ON SURGICAL OUTCOMES IN PATIENTS WITH NON-SMALL CELL LUNG CANCER. Voprosy Onkologii, 66(2), 143–147. https://doi.org/10.37469/0507-3758-2020-66-2-143-147

Abstract

Purpose: To study short-term outcomes of thermochemoradiotherapy (TCRT) followed by radical surgery in patients with non-small cell lung cancer (NSCLC). Materials and methods: The study included 38 patients with stage III lung cancer, who were treated at the Cancer Research Institute of the TNIMC (Tomsk, Russia). The study group patients (n=18) received combined modality treatment consisting of hyperfractionated radiation therapy (40 Gy total dose in twice-daily fractions of 1.3 Gy each) given concurrently with 2 cycles of chemotherapy with paclitaxel / carboplatin after 10 sessions of local hyperthermia followed by surgery. In the control group (n = 20), only surgical treatment was performed. Results: The overall tumor response to TCRT was 94.4%, including complete response (22.2%) and partial response (72.2%). All patients tolerated local hyperthermia well. All patients (100%) underwent radical surgery. There were 23 (60.5%) lobectomies, 13 (34.2%) pneumonectomies and 2 (5.3%) combined surgeries. Postoperative complications were observed in 22.2% of patients in the study group and in 20.0% of patients in the control group. The mortality rates were 0 and 5.0%, respectively (р>0.05). Conclusion: Preoperative TCRT in patients with stage III NSCLC resulted in a significant tumor regression, was well tolerated by the patients and did not have a negative impact on postoperative period and mortality.

https://doi.org/10.37469/0507-3758-2020-66-2-143-147

##article.numberofdownloads## 17

##article.numberofviews## 107

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