EXPERIMENTAL EVIDENCE FOR THE MOST EFFECTIVE MODE OF AEROSOL LAPAROSCOPIC INTRAPERITONEAL CHEMOTHERAPY (PIPAC)

ORIGINAL ARTICLES. B. EXPERIMENTAL RESEARCH

https://doi.org/10.37469/0507-3758-2017-63-3-490-496

Published 01.03.2017

Aleksandr Zakharenko⁺⁻
Sergey Bagnenko⁺⁻
Mariya Yakovleva⁺⁻
Natalya Blyum⁺⁻
Oleg Ten⁺⁻
Danila Zaytsev⁺⁻
Anton Trushin⁺⁻
Mikhail Belyaev⁺⁻
Aleksandr Natkha⁺⁻
Yu. Kovalchuk⁺⁻

Aleksandr Zakharenko

I.P. Pavlov First St. Petersburg State Medical University

Sergey Bagnenko

I.P. Pavlov First St. Petersburg State Medical University

Mariya Yakovleva

A.M. Nikiforov All-Russian Center for Emergency and Radiation Medicine

Natalya Blyum

I.P. Pavlov First St. Petersburg State Medical University

Oleg Ten

I.P. Pavlov First St. Petersburg State Medical University

Danila Zaytsev

I.P. Pavlov First St. Petersburg State Medical University

Anton Trushin

I.P. Pavlov First St. Petersburg State Medical University

Mikhail Belyaev

I.P. Pavlov First St. Petersburg State Medical University

Aleksandr Natkha

I.P. Pavlov First St. Petersburg State Medical University

Yu. Kovalchuk

I.P. Pavlov First St. Petersburg State Medical University

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Keywords

PERITONEAL CARCINOMATOSIS
REGIONAL CHEMOTHERAPY
AEROSOL CHEMOTHERAPY
PIPAC

How to Cite

Zakharenko, A., Bagnenko, S., Yakovleva, M., Blyum, N., Ten, O., Zaytsev, D., Trushin, A., Belyaev, M., Natkha, A., & Kovalchuk, Y. (2017). EXPERIMENTAL EVIDENCE FOR THE MOST EFFECTIVE MODE OF AEROSOL LAPAROSCOPIC INTRAPERITONEAL CHEMOTHERAPY (PIPAC). Voprosy Onkologii, 63(3), 490–496. https://doi.org/10.37469/0507-3758-2017-63-3-490-496

Abstract

Peritoneal carcinomatosis (PC) is one of metastatic spread variant of malignant tumors, which shows significantly poor prognosis in patients. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) - is a modern regional therapy method for implantation metastases. Currently there are still unresolved issues in native equipment, optimal chemotherapy drugs doses for PIPAC, ability in adjuvant and neoadjuvant application of method and a combination with surgical treatment. Concerning this we carried out series of experimental studies on animal model (rabbits, n=71), which resulted in development of the device for laparoscopy aerosol chemotherapy also with selection of effective and safe PIPAC mode.

https://doi.org/10.37469/0507-3758-2017-63-3-490-496

PDF (Русский)

References

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