PERIOPERATION CHANGES COLON AND RECTUM MICROBIOCINOSIS WITH COLORECTAL PATIENTS

ORIGINAL RESEARCH

https://doi.org/10.37469/0507-3758-2019-65-4-516-523

Published 01.04.2019

Aleksandr Zakharenko⁺⁻
Mikhail Belyaev⁺⁻
Oleg Ten⁺⁻
Anton Trushin⁺⁻
Vitaliy Rybalchenko⁺⁻
Sherali Dzhamilov⁺⁻
R. Kursenko⁺⁻

Aleksandr Zakharenko

Pavlov First Saint Petersburg State Medical University

Mikhail Belyaev

Pavlov First Saint Petersburg State Medical University

Oleg Ten

Pavlov First Saint Petersburg State Medical University

Anton Trushin

Pavlov First Saint Petersburg State Medical University

Vitaliy Rybalchenko

Pavlov First Saint Petersburg State Medical University

Sherali Dzhamilov

Pavlov First Saint Petersburg State Medical University

R. Kursenko

Pavlov First Saint Petersburg State Medical University

##article.numberofdownloads## 24

##article.numberofviews## 80

PDF (Русский)

Keywords

MICROBIOCENOSIS
MICROFLORA
DYSBIOSIS
COLON CANCER
INTESTINAL MICROBIOTA
DYSBACTERIOSIS
COLITIS
COLORECTAL CANCER

How to Cite

Zakharenko, A., Belyaev, M., Ten, O., Trushin, A., Rybalchenko, V., Dzhamilov, S., & Kursenko, R. (2019). PERIOPERATION CHANGES COLON AND RECTUM MICROBIOCINOSIS WITH COLORECTAL PATIENTS. Voprosy Onkologii, 65(4), 516–523. https://doi.org/10.37469/0507-3758-2019-65-4-516-523

Abstract

Most colorectal cancer patients prove to have dysbiosis of varying severity. Perioperative period contributes to the progression of the microbiocenosis disorders. It has been proven that a large role in the development of postoperative complications is played by the state of the colon microflora.

Materials. 211 colorectal cancer patient’s (T1-4N0-2M0) colon microflora was studied by PCR. Surgeries were performed laparoscopically. In the main group, developed diagnostic algorithm was used, in which initial colon flora was studied with dysbiosis progression risk determination by developed logistic regression model and perioperative correction of revealed disorders. Standards of dysbiosis treatment were used.

Results. 100% patients in control group proved to have dysbiosis of varying severity: 1 grade - 27,4% (n=14), 2 grade - 37,3% (n=19), 3 grade - 31,4% (n=16), 4 grade - 3,9% (n=2). Dysbiosis progression was observed in postoperative period: 1 grade - 7,8% (n=4), 2 grade - 51,0% (n=26), 3 grade - 29,4% (n=15), 4 grade - 11,8% (n=6). The same preoperative results were registered in main group. However, after perioperative correction there was 12,5% (n=6) 3 grade and no registered 4 grade patients. Long-term results were better in the main group than in the control group. Adverse events were significantly higher in the control group against the main group (15,7% (n=8) and 4,2% (n=2) respectively).

Discussion. We recommend preoperative stool analysis with PCR for colon microflora determination in order to further dysbiosis correction and treatment long-term results assessment.

https://doi.org/10.37469/0507-3758-2019-65-4-516-523

##article.numberofdownloads## 24

##article.numberofviews## 80

PDF (Русский)

References

Wistrom J., Ragnar Norrby S., Erling B. Myhre et al. Frequency of antibiotic-associated diarrhea in 2462 antibiotic-treated hospitalized patients a prospective study // Journal of antimicrobial chemotherapy. - 2001. - № 47. - P 43-50.

Захаренко А.А., Суворов А.Н., Шлык И.В. и др. Нарушения микробиоценоза кишечника у больных колоректальным раком и способы их коррекции // Колопроктология. - 2016. - № 2. - С. 48-56.

Bonnet M., Buc E., Sauvanet P. et al. Colonization of the human gut by E. coli and colorectal cancer risk // Clin. Cancer Res. - 2014. - Vol. 20 - P 859-867.

Ley R.E., Peterson D.A., Gordon J.I. Ecological and evolutionary forces shaping microbial diversity in the human intestine // Cell. - 2016. - № 124. - P 837-848.

Bauer M., Kuijper E., van Dissel J. European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI) // Clin. Microbiol. Infect. - 2009. - Vol. 15 - P 1067-1079.

Spigaglia P. Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection // Ther. Adv. Infect. Dis. - 2016. - Vol. 3. - № 1. - P 23-42.

Ханевич М.Д., Шашолин М.А., Зязин А.А. Колоректальный рак. Подготовка толстой кишки к операции. - М.: ИнтелТек, 2003.

Воронина О.В.: Коррекция дисбиоза у больных после операций на органах желудочно-кишечного тракта: дис. канд.мед. наук. ГМА им. И.И. Мечникова, Санкт-Петербург, 2009.

Sartelli M., Malangoni M.A., Abu-Zidan F.M., Griffiths E.A., di Bella S., et al. WSES guidelines for management of Clostridium difficile infection in surgical patients // World J. Emerg. Surg. - 2015. - Vol. 10. - № 1. - P 38.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Most read articles by the same author(s)

Ilya Vervekin , Anton Trushin , Roman Kursenko , Danila Zaitsev , Mikhail Belyaev , Alexander Zakharenko , Embryonal-based surgery for pancreatic head cancer , Voprosy onkologii : Vol. 68 No. 5 (2022)
Aleksandr Zakharenko , Mikhail Beliaev , Ilya Vervekin, Sergei Bagnenko , Application of the method of intraoperative intraperitoneal aerosol chemotherapy (PIPAC) in complex treatment of locally advanced gastric cancer with cytologically negative peritoneal lavages: the protocol for GASPACCO clinical trial , Voprosy onkologii : Vol. 68 No. 6 (2022)
Aleksandr Zakharenko, Kirill Vovin, Tatyana Kupenskaya, Vitaliy Rybalchenko, Aleksandr Natkha, Oleg Ten, Danila Zaytsev, Anton Trushin, Mikhail Belyaev, Sergey Bagnenko, FIRST RESULTS OF LAPAROSCOPIC PRESSURIZED INTRAPERITONEAL AEROSOL CHEMOTHERAPY (PIPAC) IN TREATMENT FOR PERITONEAL CARCINOMATOSIS IN PATIENTS WITH GASTRIC CANCER , Voprosy onkologii : Vol. 64 No. 2 (2018)
Aleksandr Zakharenko, Kirill Vovin, Mikhail Belyaev, Anton Trushin, T. Kupenskaya, Danila Zaytsev, Abdo Khamid, Ilya Paltyshev, OPTIMIZATION OF SURGICAL TACTICS FOR TREATING PATIENTS WITH GASTRIC CANCER IN CASE OF VARIANT ANATOMY OF THE CELIAC-MESENTERIC BASIN , Voprosy onkologii : Vol. 65 No. 4 (2019)
Aleksandr Zakharenko, Mikhail Beliaev, Sergei Bagnenko, Ilia Vervekin, Galina Iukina, Nina Tamazian, Anastasiia Novikova, Ilia Paltyshev, Comparative analysis of regional chemotherapy methods on an experimental rat model with peritoneal carcinomatosis , Voprosy onkologii : Vol. 67 No. 1 (2021)
Aleksandr Zakharenko, Kirill Vovin, Tatyana Kupenskaya, Vitaliy Rybalchenko, Aleksandr Natkha, Oleg Ten, Danila Zaytsev, Anton Trushin, Mikhail Belyaev, Sergey Bagnenko, COMPARATIVE ANALYSIS OF THE EFFICACY OF VARIOUS METHODS OF REGIONAL INTRAPERITONEAL CHEMOTHERAPY , Voprosy onkologii : Vol. 64 No. 2 (2018)
Aleksandr Zakharenko, Sergey Bagnenko, Mariya Yakovleva, Natalya Blyum, Oleg Ten, Danila Zaytsev, Anton Trushin, Mikhail Belyaev, Aleksandr Natkha, Yu. Kovalchuk, EXPERIMENTAL EVIDENCE FOR THE MOST EFFECTIVE MODE OF AEROSOL LAPAROSCOPIC INTRAPERITONEAL CHEMOTHERAPY (PIPAC) , Voprosy onkologii : Vol. 63 No. 3 (2017)
Aleksandr Zakharenko, Danila Zaytsev, Aleksandr Natkha, Mikhail Belyaev, Anton Trushin, Oleg Ten, Vitaliy Rybalchenko, INTRAPERITONEAL CHEMOTHERAPY - MODERN STATE OF THE PROBLEM , Voprosy onkologii : Vol. 63 No. 5 (2017)