РОЛЬ ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ В КАНЦЕРОГЕНЕЗЕ
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关键词

КАТАЛИТИЧЕСКАЯ А-СУБЪЕДИНИЦА ФОСФАТИДИЛИНОЗИТОЛ-4
АПОПТОЗ
КАНЦЕРОГЕНЕЗ

How to Cite

Оськина, Н., Щербаков, А., Филипенко, М., Кушлинский, Н., & Овчинникова, Л. (2017). РОЛЬ ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ В КАНЦЕРОГЕНЕЗЕ. VOPROSY ONKOLOGII, 63(4), 545–556. https://doi.org/10.37469/0507-3758-2017-63-4-545-556

摘要

В настоящее время общепринятой считается мутационная теория канцерогенеза, согласно которой в основе злокачественной трансформации лежит изменение генома клетки. Сигнальный каскад PI3K/Akt/mTOR является важным регулятором клеточного роста и метаболизма, а его патологическая активация обнаружена при различных онкологических заболеваниях. В данном обзоре рассмотрены изменения в PI3K сигнальном каскаде при различных онкопатологиях и обсуждается возможность их практического применения в диагностике и терапии.
https://doi.org/10.37469/0507-3758-2017-63-4-545-556
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