Ключевые слова
Как цитировать
Аннотация
Иммунный синапс (ИС) - высокоспециализированное соединение между Т-лимфоцитом и антигенпрезентирующей клеткой (АПК), состоящее из центрального кластера рецепторов Т-клеток, окруженное кольцом молекул адгезии. В настоящее время показано, что образование иммунных синапсов является активным и динамичным механизмом, который позволяет Т-клеткам различать потенциальные антигенные лиганды. На первом этапе формирования иммунного синапса лиганды рецепторов Т-клеток задействованы во внешнем кольце формирующегося синапса. Перемещение этих комплексов в центральный кластер зависит от кинетики взаимодействия молекул Т-клеточный рецептор-лиганд. Таким образом, формирование стабильного центрального кластера в иммунном синапсе является определяющим событием для активации и пролиферации Т-лимфоцитов. Использование эффективных способов воздействия на ИС и внедрение в практику новых противоопухолевых препаратов, модуляторов иммунного синапса позволяет по-новому взглянуть на возможности иммунотерапии опухолей.
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