Vol. 65 No. 6 (2019), ORIGINAL ARTICLES. C. EXPERIMENTAL RESEARCH

Vol. 65 No. 6 (2019)

THE STUDY OF CIRCADIAN RHYTHMS IN OVARIAN CANCER RAT MODEL: IS THERE CONNECTION BETWEEN TUMOR DEVELOPMENT AND RHYTHMICITY DISRUPTION IN INTACT TISSUES?

ORIGINAL ARTICLES. C. EXPERIMENTAL RESEARCH

https://doi.org/10.37469/0507-3758-2019-65-6-889-897

Published 01.06.2019

Galina Kireeva⁺⁻
Yekaterina Gubareva⁺⁻
Natalya Mityushkina⁺⁻
Andrey Panchenko⁺⁻
Mikhail Maydin⁺⁻
Margarita Tyndyk⁺⁻
I. Gavrilov⁺⁻
Stepan Kruglov⁺⁻
Yevgeniya Kharchenko⁺⁻
Vladimir Anisimov⁺⁻

Galina Kireeva

N.N. Petrov National Medical Research Center of Oncology, the Ministry of Healthcare of the Russian Federation

Yekaterina Gubareva

N.N. Petrov National Medical Research Center of Oncology, the Ministry of Healthcare of the Russian Federation

Natalya Mityushkina

N.N. Petrov National Medical Research Center of Oncology, the Ministry of Healthcare of the Russian Federation

Andrey Panchenko

N.N. Petrov National Medical Research Center of Oncology, the Ministry of Healthcare of the Russian Federation

Mikhail Maydin

N.N. Petrov National Medical Research Center of Oncology, the Ministry of Healthcare of the Russian Federation

Margarita Tyndyk

N.N. Petrov National Medical Research Center of Oncology, the Ministry of Healthcare of the Russian Federation

I. Gavrilov

N.N. Petrov National Medical Research Center of Oncology, the Ministry of Healthcare of the Russian Federation

Stepan Kruglov

N.N. Petrov National Medical Research Center of Oncology, the Ministry of Healthcare of the Russian Federation

Yevgeniya Kharchenko

N.N. Petrov National Medical Research Center of Oncology, the Ministry of Healthcare of the Russian Federation

Vladimir Anisimov

N.N. Petrov National Medical Research Center of Oncology, the Ministry of Healthcare of the Russian Federation

PDF (Русский)

Keywords

BMAL1
CLOCK
CRY1
PER2
CIRCADIAN RHYTHMS
CLOCK GENES
OVARIAN CANCER
RAT MODEL

How to Cite

Kireeva, G., Gubareva, Y., Mityushkina, N., Panchenko, A., Maydin, M., Tyndyk, M., Gavrilov, I., Kruglov, S., Kharchenko, Y., & Anisimov, V. (2019). THE STUDY OF CIRCADIAN RHYTHMS IN OVARIAN CANCER RAT MODEL: IS THERE CONNECTION BETWEEN TUMOR DEVELOPMENT AND RHYTHMICITY DISRUPTION IN INTACT TISSUES?. Voprosy Onkologii, 65(6), 889–897. https://doi.org/10.37469/0507-3758-2019-65-6-889-897

Abstract

Considering emerging yet contradictory data on circadian rhythms disruption and its effects on tumor initiation and progression, we performed in vivo study to evaluate changes (if any) in clock genes expression in tumor compared to intact tissues as well as to see if tumor development affects normal tissues in tumor-bearing animals. The study was performed in 75 female Wistar rats, intraperitoneally transplanted ovarian cancer was used as a tumor model. Tumor-bearing rats had fragmented circadian rhythmicity of their locomotor activity compared to intact animals. No circadian rhythmicity in proliferation of tumor cells was detected. Precise proliferative rhythmicity was found in normal cells (intestinal epithelium) of intact rats, while significant disruption in such rhythmicity was observed in the same cells of tumor-bearing rats. Average clock genes (BMAL1, CLOCK, CRY1, PER2) expression rate was significantly reduced in tumor cells compared to intact tissues. The data from these experiments let us choosing 2 time points to perform chemotherapy in the following study where effects of chronochemotherapy will be evaluated.

https://doi.org/10.37469/0507-3758-2019-65-6-889-897

PDF (Русский)

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