CIRCADIAN RHYTHM OF PROLIFERATION IN INTESTINAL EPITHELIUM AND MAMMARY TUMORS IN HER-2/NEU TRANSGENIC AND FVB/N WILD TYPE MICE; THEIR CORRECTION WITH MELATONIN

ORIGINAL ARTICLES. C. EXPERIMENTAL RESEARCH

https://doi.org/10.37469/0507-3758-2019-65-1-154-158

Published 01.01.2019

Yekaterina Gubareva⁺⁻
Mikhail Maydin⁺⁻
Margarita Tyndyk⁺⁻
Irina Vinogradova⁺⁻
Andrey Panchenko⁺⁻

Yekaterina Gubareva

N.N. Petrov National Medical Research Center of Oncology Ministry of Healthcare of the Russian Federation

Mikhail Maydin

N.N. Petrov National Medical Research Center of Oncology Ministry of Healthcare of the Russian Federation

Margarita Tyndyk

N.N. Petrov National Medical Research Center of Oncology Ministry of Healthcare of the Russian Federation

Irina Vinogradova

Petrozavodsk State University

Andrey Panchenko

N.N. Petrov National Medical Research Center of Oncology Ministry of Healthcare of the Russian Federation

##article.numberofdownloads## 43

##article.numberofviews## 98

PDF (Русский)

Keywords

ТРАНСГЕННЫЕ ПО HER-2/NEU
MAMMARY CANCER
HER2/NEU TRANSGENIC MICE
MELATONIN
CIRCADIAN RHYTHMS

How to Cite

Gubareva, Y., Maydin, M., Tyndyk, M., Vinogradova, I., & Panchenko, A. (2019). CIRCADIAN RHYTHM OF PROLIFERATION IN INTESTINAL EPITHELIUM AND MAMMARY TUMORS IN HER-2/NEU TRANSGENIC AND FVB/N WILD TYPE MICE; THEIR CORRECTION WITH MELATONIN. Voprosy Onkologii, 65(1), 154–158. https://doi.org/10.37469/0507-3758-2019-65-1-154-158

Abstract

Circadian rhythms and tumor development are interconnected as the factors like light pollution which disrupt circadian rhythms increase the risk of cancer, and oncological diseases are associated with changes in organism’s circadian rhythms. Circadian changes in intestinal epithelium and mammary tumors proliferation and apoptosis in HER-2/neu overexpressing FVB/N mice and assessment of melatonin’s influence on these parameters were studied in this work. It was shown by us that intestinal epithelium in mice exhibits circadian rhythm of proliferation with the peak in the morning and in tumor-bearing mice this rhythm is disrupted. Exogenous melatonin contributes to circadian rhythm of intestinal epithelium proliferation. Circadian changes in mammary tumors proliferation rate depend on melatonin secretion or supplementation time. Thus, melatonin may be considered as a perspective drug in anticancer therapy modulating circadian rhythms in cancerous and normal tissues.

https://doi.org/10.37469/0507-3758-2019-65-1-154-158

##article.numberofdownloads## 43

##article.numberofviews## 98

PDF (Русский)

References

Канцерогенез / Под ред. Д.Г. Заридзе. - М: Медицина, 2004. - 576 с

Anisimov V.N., Popovich I.G., Zabezhinski M.A., et al. Melatonin as antioxidant, geroprotector and anticarcinogen // Biochimica et Biophysica Acta. - 2006. - Vol. 1757(5 6). - P. 573-589

Benloucif, S., Dubocovich, M. L. Melatonin and Light Induce Phase Shifts of Circadian Activity Rhythms in the C3H/HeN Mouse // Journal of Biological Rhythms. -1996. - Vol. 11(2). - P. 113-125.

Blask, D. E., Dauchy, R. Т., Sauer, L. A., et al. Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppression // Breast Cancer Research and Treatment. - 2003. - Vol. 79(3). - P. 313-20.

Cos S., Blask D.E., Lemus-Wilson A., Hill A. B. Effects of melatonin on the cell cycle kinetics and «estrogen-rescue» of MCF-7 human breast cancer cells in culture // Journal of Pineal Research. - 1991. - Vol. 10(1). - P. 36-42.

Di Bella G., Mascia F., Gualano L., Di Bella L. Melatonin anticancer effects: review // International Journal of Molecular Sciences. - 2013. - Vol. 14(2). - P. 2410-30.

Fanjul-Moles M.L., Lopez-Riquelme G.O. Relationship between Oxidative Stress, Circadian Rhythms, and AMD // Oxidative Medicine and Cellular Longevity. - 2016. -Vol. 2016. - P. 1-18.

Inacio Pinto N., Carnier J., Oyama et al. Cancer as a Proinflammatory Environment: Metastasis and Cachexia // Mediators of Inflammation. - 2015. - Vol. 2015. - P. 1-13.

Konturek, P. C., Brzozowski, T., Konturek, S. J. Gut clock: implication of circadian rhythms in the gastrointestinal tract // Journal of Physiology and Pharmacology. - 2011. - Vol. 62(2). - P. 139-50.

Leon-Blanco, M. M., Guerrero, J. M., Reiter et al. Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitro // Journal of Pineal Research. - 2003. - Vol. 35(3). - P. 204-11.

Mormont, M.-C., Levi, F. Cancer chronotherapy: Principles, applications, and perspectives // Cancer. - 2003. - Vol. 97(1). - P. 155-169.

Panchenko A.V., Popovich I.G., Trashkov A.P. et al. Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N. female mice // Biogerontology. - 2016. - Vol. 17(2). - P. 317-324.

Payne J.K. Altered Circadian Rhythms and Cancer-Related Fatigue Outcomes // Integrative Cancer Therapies. - 2011. - Vol. 10(3). - P. 221-233.

Redon C.E., Dickey J.S., Nakamura A.J. et al. Tumors induce complex DNA damage in distant proliferative tissues in vivo // Proc. Natl. Acad. Sci. U. S. A. - 2010. - Vol. 107. P. 17992-17997.

Reiter R.J., Rosales-Corral S.A., Tan D.-X. et al. Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis // International Journal of Molecular Sciences. - 2017. - Vol. 18(4). - P. 843.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Most read articles by the same author(s)

Margarita Tyndyk, Irina Popovich, A. Malek, R. Samsonov, N. Germanov, S. Golyadin, S. Mochalov, Sergey Pulnev, Viktor Anisimov, ANTITUMOR EFFECT OF COLLOIDAL SILVER BISILICATE IN EXPERIMENTAL IN VITRO AND IN VIVO STUDIES , Voprosy onkologii : Vol. 65 No. 5 (2019)
Sergey Orlov, Aram Musaelyan, Juliet Kochesokova, Svetlana Odintsova, Fedor Zagrebin, Vladislav Tyurin, Mikhail Maydin, Alexey Degtyarev , Evgeniy Imyanitov , Capmatinib in patients with MET-positive advanced non-small cell lung cancer: analysis of the Russian cohort in the Geometry mono-1 study , Voprosy onkologii : Vol. 68 No. 6 (2022)
Galina Kireeva, Stepan Kruglov, A. Tarasov, Ye. Plakhov, Yekaterina Gubareva, Mikhail Maydin, Andrey Panchenko, Tatyana Grishacheva, MODIFICATING ACTION OF DICLOFENAC ON EFFECTS OF PHOTODYNAMIC THERAPY – IN VIVO STUDY , Voprosy onkologii : Vol. 65 No. 3 (2019)
Ivan Anikin, Yekaterina Gubareva, Mikhail Maydin, Margarita Tyndyk, EFFECT OF ε-AMINOCAPROIC ACID ON THE GROWTH OF AN INOCULATED ASCITIC AND SOLID EHRLICH TUMOR OF MICE , Voprosy onkologii : Vol. 63 No. 6 (2017)
Mikhail Osipov, Tatyana Semiglazova, Irina Popovich, Andrey Panchenko, Margarita Tyndyk, Mark Zabezhinskiy, Veronika Klimenko, Aleksandr Stukov, Vladimir Anisimov, EFFECT OF METFORMIN, MELATONIN AND THEIR COMBINATIONS WITH PACLITAXEL ON THE GROWTH OF TRANSPLANTABLE HER2-POSITIVE BREAST TUMOR IN FEMALE FVB/N MICE , Voprosy onkologii : Vol. 63 No. 4 (2017)
Mariya Yurova, Margarita Tyndyk, Yekaterina Gubareva, Yelena Fedoros, Viktor Anisimov, THE EFFECTS OF THE COMBINATION OF RAPAMYCIN WITH DOXORUBICIN AND PACLITAXEL ON THE MODELS OF TRANSPLANTABLE TUMORS IN MICE , Voprosy onkologii : Vol. 65 No. 4 (2019)
Ye. Gubareva, A. Panchenko, Mikhail Maydin, Ye. Fedoros, Margarita Tyndyk, G. Lnus, Vladimir Anisimov, Galina Kireeva, DISRUPTED DAILY OSCILLATIONS OF CLOCK GENES EXPRESSION AND CLOCK PROTEINS CONTENT IN TUMORS AND DISTANT TISSUES IN HER2/NEU TRANSGENIC MICE , Voprosy onkologii : Vol. 66 No. 5 (2020)
Galina Kireeva, Katran Guseynov, Georgiy Gafton, Aleksandr Semenov, Mikhail Maydin, Aleksandr Stukov, Konstantin Senchik, Olesya Belyaeva, Vladimir Bespalov, Aleksey Belyaev, OPEN TECHNIQUE OF HYPERTHERMIC INTRAPERITONEAL CHEMOPERFUSION IN TREATMENT OF PERITONEAL CARCINOMATOSIS IN RATS WITH ASCITIC OVARIAN TUMOR , Voprosy onkologii : Vol. 63 No. 5 (2017)
Andrey Panchenko, Yevgeniy Plakhov, Yekaterina Gubareva, Lyudmila Guzevatykh, K. Khitrin, V. Balabanyan, MODELING OF SOLID LIVER CANCER IN A RABBIT , Voprosy onkologii : Vol. 63 No. 5 (2017)
Ekaterina Gubareva, Mariia Iurova, Margarita Tyndyk, Mikhail Maydin, Grigorii Yanus, Petr Egormin, Andrey Panchenko, Vladimir Anisimov, The effect of constant light and melatonin on urethane-induced lung carcinogenesis in mice and expression of clock genes and proteins , Voprosy onkologii : Vol. 67 No. 3 (2021)

1 2 > >>