Abstract
The antitumor activity of the antifibrinolytic drug ε-aminocaproic acid (ACC) in the therapeutic form (5% ACC solution in physiological solution instead of drinking water) was studied in the ascitic and solid Ehrlich tumor. ACC did not affect the growth of ascitic, as well as a solid Ehrlich tumor, when the drug was administered 72 hours after the tumor inoculation. At the same time, when it was administered 7 days after tumor inoculation, the drug had a statistically significant antitumor effect on the tumor nodes formed (8-10 mm in diameter). ACC antitumor effect allows to assume that it influences tumor stroma rather than the parenchyma. This effect is not fully understood and needs further study.References
Аникин И.В., Тындык М.Л., Забежинский М.А. и др. Влияние Е-аминокапроновой кислоты, циклофосфа-мида и их комбинации на рост аутохтонных индуцированных бенз(а)пиреном сарком мышей // Вопросы Онкологии. - 2014. - Т. 1. - С. 94-95.
Беспалов В.Г., Александров ВА, Петров А.С., Троян Д.Н. Тормозящее влияние е-аминокапроновой кислоты на частоту индуцированных опухолей пищевода, нервной системы и почек // Вопр. онкол. - 1992. - Т. 38. - № 1. - С. 69-74.
Экспериментальная оценка противоопухолевых препаратов в СССР и США / Под ред. Софьиной З.П., Сыркина А.Б., Голдина А., Клейн А. - Москва: Медицина, 1979. - 296 с.
Afsharimani B., Cabot P.J., Parat M.O. Effect of lysine antifibrinolytics and cyclooxygenase inhibitors on the proteolytic profile of breast cancer cells interacting with macrophages or endothelial cells // Br. J. Anaesth. - 2014. - Vol. 113. - P. i22-31.
Corasanti J.G., Hobika G.H., Markus G. Interference with dimethylhydrazine induction of colon tumors in mice by epsilon-aminocaproic acid // Science. - 1982. - Vol. 216. - P. 1020-1021.
Gavilondo J., Pérez R., Mainardi V., Lage A. Effect of two antiproteinases on the growth of transplantable tumors and the proliferation of untransformed and transformed cells in culture // Neoplasma. - 1982. - Vol. 29. - P. 315-322.
Kirstein J.M., Graham K.C., MacKenzie L.T., Johnston D.E., Martin L.J., Tuck A.B. Effect of anti-fibrinolytic therapy on experimental melanoma metastasis // Clin. Exp. Metastasis. - 2009. - Vol. 26. - P. 121-131.
Pan C.W., Shen Z.J., Ding G.Q. The Effect of Intravesical Instillation of Antifibrinolytic Agents on Bacillus Calmette-Guerin Treatment of Superficial Bladder Cancer: A Pilot Study. // J. Urol. - 2008. - Vol. 179. - P. 1307-1312.
Perides G., Zhuge Y, Lin T., Stins M.F., Bronson R.T, Wu J.K. The fibrinolytic system facilitates tumor cell migration across the blood-brain barrier in experimental melanoma brain metastasis // BMC Cancer. - 2006. - Vol. 6. - P 56.
Sawaya R., Mandybur T., Ormsby I., Tew J.M. Antifibrinolytic therapy of experimentally grown malignant brain tumors // J. Neurosurg. - 1986. - Vol. 64. - P. 263-268.
Viedma-Rodriguez R., Martinez-Hernandez M.G., FloresLopez L.A., Baiza-Gutman L.A. Epsilon-aminocaproic acid prevents high glucose and insulin induced-invasiveness in MDA-MB-231 breast cancer cells, modulating the plasminogen activator system // Mol. Cell Biochem. - 2017. - DOI: 10.1007/s11010-017-3096-8
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