Voprosy onkologii

Current Issue

Vol. 71 No. 6 (2025)

Published 30.12.2025

The scientific and practical journal "VOPROSY ONKOLOGII" is the official peer-reviewed publication of the Federal State Budgetary Institute N.N. Petrov National Medical Research Center of Oncology Ministry of Health of the Russian Federation. It has been published since 1928. The journal is dedicated to the study of malignant neoplasms and their treatment. It is included in the list of leading peer-reviewed scientific publications of the Higher Attestation Commission of Russia (НАС), recommended for the publication of articles containing materials of candidate and doctoral dissertations. The publication is indexed by the Scopus, Russian Science Citation Index (RSCI) based on Web of Science.

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Журнал № 6-2025 (Русский)

FROM the EDITOR-in-CHIEF

Alexey M. Belyaev

1225-1226

Message Editor-in-Chief of the journal «Voprosy Onkologii»

https://doi.org/10.37469/0507-3758-2025-71-6-1225-1226

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EDITORIALS

Vitaly V. Omelyanovskiy, Julia A. Agafonova, Ildar I. Khayrullin, Zhanna V. Khailova, Yuriy I. Komarov, Kirill I. Kirgizov, Sergey A. Ivanov, Andrey D. Kaprin

OF-2469

Assessing National Healthcare System Readiness for Value-Based Healthcare Models Implementation

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2469

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Irina Anatolievna Demidova, Svetlana Nikolaevna Aleksakhina, Аlexander Evgenievich Druy, Tatiana Vladimirovna Kekeeva, Alexander Sergeevich Martianov, Yana Igorevna Tretiakova, Natalia Andreevna Firsova, Maxim Leonidovich Filipenko, Grigory Anatolievich Tsaur, Alexey Sergeevich Tsukanov, Evgeny Naumovich Imyanitov

OF-2485

Interlaboratory Quality Control of BRAF Mutation Testing: The Experience of the Russian Organization of Molecular Geneticists in Oncology and Oncohematology

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2485

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Ivan Alexandrovich Kurnosov, Pavel Vasilyevich Balakhnin, Dmitry Alexandrovich Gulyaev, Daria Romanovna Subbotina, Vasilii Igorevich Malkevich, Anastasia Leonidovna Muravtseva, Aleksei Stanislavovich Shmelev, Vladislav Yuryevich Chirkin, Ilya Alexandrovich Burovik, Bagnenko Sergey Sergeevich, Aleksey Mikhailovich Belyaev

OF-2310

Flat-Detector Computed Tomography: Advancing Real-Time Neuronavigation for Stereotactic Brain Tumor Biopsy

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2310

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STATISTICS

Vakhtang M. Merabishvili, Alexey M. Karachun, Alexey M. Belyaev

OF-2389

The State of Cancer Care in Russia: Gastric Cancer (C16). Prevalence, Data Registry Quality (Population Study)

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2389

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Nilufar A. Muhsinzoda , Gafur M. Muhsinzoda , Safarkhon S. Sattorov , Rustam Abdusamad Tursunzoda

OF-2282

Prevalence of Human Papillomavirus Infection and Cervical Pathology in Women with Different HIV Statuses

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2282

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ORIGINAL ARTICLES. CLINICAL RESEARCH

Vasily Bogdanovich Vasilyuk, Maria Valerevna Faraponova , Alexey Borisovich Verveda, Gulnara Ислямовна Syraeva, Alexey Leonidovich Kovalenko

OF-2386

A Single-Dose Pharmacokinetic and Bioequivalence Study of Generic and Original Aprepitant in Healthy Volunteers

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2386

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Olga Viktorovna Romanchuk, Denis Yurevich Yukalchuk, Roman Sergeevich Zhikhorev, Maria Sergeevna Perminova, Sergey Borisovich Belonogov, Maria Ivanovna Antoshkina, Tatiana Valeryevna Garmarnik, Nadezhda Vitalyevna Leushina, Elena Ivanovana Rossokha, Irina Mikhaylovna Radyukova, Aleksey Aleksandrovich Askarin, Oleg Vyacheslavovich Mironov, Александр Валерьевич Султанбаев, Александр Сергеевич Дергунов

OF-2493

ORCHIDEA: A Retrospective Study of Patient Demographics, Clinical Characteristics, and Adjuvant Therapy Patterns in Stage II–III HR+/HER2– Breast Cancer Within Routine Clinical Practice

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2493

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Maria Vladimirovna Berkut, Anna Igorevna Semenova, Alexey Viktorovich Novik, Dilorom Khamidovna Latiphova, Gulfia Midhatovna Teletaeva, Ekaterina Alexandrovna hishaeva, Alexander Konstantinovich Nosov

OF-2308

Comparative Analysis of Standard and Split-Dose Cisplatin in Neoadjuvant Chemotherapy for Bladder Cancer

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2308

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Olesya A. Kuchevskaya, Yuri S. Esakov, Zurab G. Tukvadze , Ilya A. Pokataev , Tatiana G. Antonova , Olesya A. Stativko , Evgenia S. Kuzmina, Maria A. Lyadova , Sergey A. Parts , Vsevolod N. Galkin , Vitalii G. Shatalov , Evgenia A. Kulikova

OF-2369

Single-center, non-randomized, prospective phase II study evaluating the effectiveness of induction chemoimmunotherapy in the combined outcome of locally advanced non-small cell lung disease

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2369

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Andrey Victorovich Karpenko, Ramil Rustamovich Sibgatullin, Alexandr Alexandrovich Boyko, Olga Michailovna Nikolayeva

OF-2235

Transoral Management of Oral Cancer with Variable Depth of Invasion

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2235

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Denis E. Kulbakin , Vladimir Ivanovich Chernov, Ekaterina A. Smolina, Evgeny L. Choynzonov, Irina K. Fedorova, Elena V. Obkhodskaya, Artem V. Obkhodskiy, Vladislav O. Tshai, Evgeniy O. Rodionov, Sergey V. Miller, Vladislav Sergeevich Lakonkin , Victor I. Sachkov

OF-2419

Diagnostic Potential of a Multisensor Gas Analysis System and Artificial Intelligence for Upper Respiratory Tract Cancer. A Single-Center Study Results

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2419

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Svetlana N. Tamkovich, Natalia N. Yunusova, Dmitry A. Svarovsky, Tatiana A. Shtam, Irina V. Kondakova, Alyona L Chernyshova

OF-2500

Exosomal Proteasome Levels as a Potential Biomarker for Differentiating Mastopathy from Breast Cancer via Liquid Biopsy

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2500

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Kseniia Vyacheslavovna Kozubova, Ekaterina Aleksandrovna Busko, Denis Valeryevich Nesterov, Ilya Aleksandrovich Burovick, Sergey Sergeevich Bagnenko, Roman Andreevich Kadyrleev, Elvira Sergeevna Filonova, Valeriia Valeryevna Nesterova, Pavel Vasilievich Balahnin

OF-2539

Comparative Diagnostic Performance of Multiparametric Ultrasound Versus Contrast-Enhanced Computed Tomography the Differential Diagnosis of Focal Liver Lesions in Colorectal Cancer

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2539

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Valeriia V. Nesterova, Denis V. Nesterov, Ilya A. Burovik, Sergey S. Bagnenko, Pavel V. Balakhnin, Anna V. Kulish, Pavel Yu. Grishko, Aleksei S. Shmelev, Vasilii I. Malkevich, Evgeny V. Zagaynov, Aleksei M. Karachun, Ekaterina A. Busko, Ksenia V. Kozubova, Anna S. Mamontova, Igor I. Yarmolyuk

OF-2399

CT Arteriography for Assessing Colorectal Cancer Liver Metastases After Systemic Drug Therapy

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2399

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ORIGINAL ARTICLES. EXPERIMENTAL RESEARCH

Olesya Aleksandrovna Vasilyeva, Ekaterina Yaroslavovna Kadantseva, Alexandr Yurievich Garanin , Lidia Mihaylovna Zabegina, Dmitry Alexandrovich Surov, Anastasia Valer'evna Malek

OF-2525

Extracellular Vesicle and DNA Aptamer-Based Targeted Delivery System for Doxorubicin to Ovarian Cancer Cells

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2525

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Svetlana V. Valueva, Andrey V. Panchenko, Polina Yu. Morozova, Alexander L. Semenov, Anna B. Danilova, Stepan S. Kruglov

OF-2489

Selenium-Based Three-Component Nanosystem for Photodynamic Therapy: In Vitro and In Vivo Evaluation of Cellulose Graft Copolymer and Radachlorin Formulation

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2489

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EXPERIENCE OF ONCOLOGY CLINICS

Oxana Nikolaevna Shkodenko, Valeria Olegovna Kubyshkina, Yasiin Akhmedovich Mukhadinov, Konstantin Vladimirovich Khurtsev, Arsen Askerovich Koichuev

OF-2376

Comparative Efficacy of Anastrozole, Letrozole, and Fulvestrant as Endocrine Partners Combined with CDK4/6 Inhibitors in Patients with HR+/HER2– Metastatic Breast Cancer: A Real-World Evidence from the Stavropol Regional Clinical Oncology Center

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2376

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##article.numberofviews## 80

Arsen Osmanovich Rasulov , Iurii Mikhailovich Stoyko , Artur Eduardovich Kulikov , Jasur Makhirovich Madyarov , Zaur Rabadankadievich Rasulov , Andrey Vladimirovich Maksimenkov , Andrey Vladimirovich Botov, Sherif Alishikhovich Alishikhov, Ruslan Arsenovich Rasulov , Andrei Vasilyevich Vinogradov

OF-2343

Minimally Invasive Restorative Surgery for Low-Lying Rectal Carcinoma Patients

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2343

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Aleksei Arievich Kashintsev, Nikolai Yurievich Kokhanenko, Konstantin Vadimovich Pavelets, Ivan Anatolyevich Soloviev, Dmitriy Sergeevich Rusanov, Olga Grigorievna Vavilova; Yuri Vasilievich Radionov; Mikhail Sergeevich Dinikin, Mikhail Yurievich Agapov, Yuri Vasilievich Pelipas; Yuri Alekseevich Gulyaev, Temuri Shokroevich Morgoshia, Farida Gabdrokhmanovna Magomedova; Lyudmila Aleksandrovna Solovyova; Anastasia Andreevna Nadeeva; Anna Sergeevna Borovikova; Kirill Vladimirovich Laptev, Alexander Vasilievich Lemeshev; Vitali Yurievich Proutski

OF-2340

Clinical Application of Active Aspiration Fluid Biopsy for Pancreatic Neoplasia Diagnosis in Oncology Practice

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2340

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CLINICAL CASES

Aleksandra M. Konova, Ekaterina Yu. Zorina, Sofia S. Sklyar, Ivan N. Danilov, Elena A. Ulrikh

OF-2333

Successful Management of Nasal Cavity and Paranasal Sinus Neuroendocrine Carcinoma with Upper Airway Obstruction During Pregnancy: A Case Report

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2333

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Evgeniy O. Rodionov, Nicolay V. Vasilyev, Sergey V. Miller, Vera M. Kolmakova

OF-2288

Primary Multiple Malignant Peripheral Nerve Sheath Tumors with Hematogenous and Lymphatic Metastases in Neurofibromatosis Type 1: A Case Report

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2288

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REVIEWS

Aglaya G. Iyevleva, Svetlana N. Aleksakhina, Anna P. Sokolenko, Ekaterina A. Otradnova, Ekaterina Sh. Kuligina, Evgeny N. Imyanitov

OF-2326

DNA Homologous Recombination Repair Gene Mutations in Prostate Cancer: Predictive Significance and Role in Hereditary Predisposition

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2326

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Valentina V. Litvinova ; Alina Egenievna Solopova; Grigorii Nikolaevich Khabas, Dmitry Leonidovich Ovodenko

OF-2352

Preoperative Differential Diagnosis of Uterine Sarcomas: Current Considerations and Challenges

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2352

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Anna D. Darenskaya, Bela M. Medvedeva, Tigran G. Gevorkyan, Alexander V. Petrovsky, Iuliia V. Molostova

OF-2405

Texture Analysis of MR Imaging for Hepatocellular Cancer Diagnosis: Reality and Prospects (Literature Review)

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2405

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Diana T. Kabirova, Irina L. Lipskaya, Georgiy G. Prokhorov, Ilya A. Burovik, Evgeniy V. Levchenko

OF-2316

Cryoablation for Primary and Metastatic Lung Tumors: A Contemporary Perspective

https://doi.org/10.37469/0507-3758-2025-71-6-OF-2316

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ANNIVERSARY

Elena A. Jenkova

1490-1491

Zlatnik E.Yu. (on her 70th birthday)

https://doi.org/10.37469/0507-3758-2025-71-6-1490-1491

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View All Issues

The scientific and practical journal "VOPROSY ONKOLOGII" included in the list of leading peer-reviewed scientific publications of the Higher Attestation Commission of Russia (НАС), recommended for the publication of articles containing materials of candidate and doctoral dissertations. The publication is indexed by the Scopus, Russian Science Citation Index (RSCI) based on Web of Science.

The journal provides immediate open access to its content under the Diamond Open Access model, based on the following principle: free dissemination of academic knowledge among readers - publications are fully accessible to readers free of charge, and there are no publication fees. Full-text materials are available open access under the Creative Commons CC-BY.

The journal is registered with the Federal Service for Supervision of Communications, Information Technology and Mass Media (Roskomnadzor).

Certificate of registration of mass media - PI No. FS77 47156 of 3 November 2011.

ISSN 0507-3758 (Print)
ISSN 2949-4915 (Online)