Voprosy onkologii

Current Issue

Vol. 71 No. 4 (2025)

Published 11.09.2025

The scientific and practical journal "VOPROSY ONKOLOGII" is the official peer-reviewed publication of the Federal State Budgetary Institute N.N. Petrov National Medical Research Center of Oncology Ministry of Health of the Russian Federation. It has been published since 1928. The journal is dedicated to the study of malignant neoplasms and their treatment. It is included in the list of leading peer-reviewed scientific publications of the Higher Attestation Commission of Russia (НАС), recommended for the publication of articles containing materials of candidate and doctoral dissertations. The publication is indexed by the Scopus, Russian Science Citation Index (RSCI) based on Web of Science.

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Журнал 4-2025 (Русский)

FROM EDITION

695-695

Introductory Remarks, Doctor of Medical Sciences, Novik A.V.

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EDITORIALS

Vitaly V. Omelyanovskiy, Julia A. Agafonova, Polina A. Mukhortova, Filipp V. Gorkavenko, Yuriy I. Komarov, Zhanna V. Khailova, Andrey D. Kaprin

OF-2305

Endpoints and Outcomes in Real-World Oncology Clinical Trials

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2305

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STATISTICS

Vakhtang M. Merabishvili, Lev V. Demidov, Igor V. Samoilenko, Alexey M. Belyaev

OF-2388

The State of Oncology Care for Melanoma Skin Cancer (C43) in Russia: One- and Five-Year Patient Survival. Localization and Histological structure (A Population-Based Study)

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2388

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Dmitry D. Gromov, Petr Andreevich Kurchatov, Oksana Anatol'evna Afinogenova, Marija Andreevna Zajarnaja, Maksim Andreevich Bogdanov, Dmitry Vasilyevich Bogdanov, Andrey Andreevich Dyachenko, Ekaterina Aleksandrovna Nazarova, Elena Fedorovna Potekhina, Anna Viktorovna Agaeva, Anna Andreevna Elizarova, Mihail Evgen'evich Bulanov, Anna Aleksandrovna Meldo, Valerija Jur'evna Chernina, Lyudmila Evgenevna Val`kova, Mihail Jur'evich Vereshhagin, Aleksandr Leonidovich Popov, Aleksandr Valer'evich Kudrjavcev, Andrej Mechislavovich Grzhibovskij, Viktor Aleksandrovich Gombolevskij, Mikhail Yur`evich Val`kov

OF-2335

Non-Oncologic Causes of Mortality in Cancer Patients: A 15-Year Population-Based Analysis

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2335

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Petr A Kurchatov, Dmitry V Bogdanov, Elena F Potekhina, Andrey V Berezin, Olga M Vtoraya, Mikhail Yu Valkov

OF-2260

Time to Surgery for Radical Resection Patients as a Survival Predictor in Gastric Cancer: A Population-Based Study

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2260

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ORIGINAL ARTICLES. C. CLINICAL RESEARCH

Tatiana Lenidovna Nekhaeva, Aleksey Victorovich Novik, Natalya Aleksandrovna Efremova, Anna Borisovna Danilova, Polina Alekseevna Savchenko, Bogdan Nikolaevich Davydenko, Irina Alexandrovna Baldueva

OF-2437

The Autologous CaTeVac Dendritic Cell Vaccine in Patients with Melanoma: Final Results of the DENDRON-01 Study

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2437

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Zakhra Magomedova, Valeria Nazarova, Kristina Orlova, Ekaterina Azarova, Vladimir Unguryan, Denis Romanov, Roman Moskalenko, Rafael Fayzullin, Oxana Trofimova, Lev Demidov

OF-2398

Immunotherapy Combined with Stereotactic Radiotherapy or Isolated Hepatic Perfusion for Metastatic Uveal Melanoma: Preliminary Study Results

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2398

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Konstantin V. Lyadov , Aleksei.N. Moskalenko , Yury. E Kopychev , Nikita.A Khoronenko , Nikolay.V Markov, Vladimir. K Lyadov

OF-2248

Selective Transarterial Yttrium-90 Radioembolization for Hepatic Metastases: A Case Series

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2248

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Ada V. Anisimova, Svetlana Petrovna Vorob'eva, Alexey Georgyevich Manikhas , Vladimir Anatolyevich Ershov, Georgy Moyseevich Manikhas, Eldar Eskenderovych Topuzov

OF-2337

The Mechanism of Early Lymphogenic Metastasis of Skin Melanoma

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2337

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Aleksei Novik, Kristina Yurievna Kapusta, Tatiana Leonidovna Nekhaeva, Anna Borisovna Danilova, Andrei Vladimirovich Orekhov , Egor Vladimirovich Vasilev, Dilorom Khamidovna Latipova , Anna Igorevna Semenova , Liliia Sergeevna Baboshkina, Gulfiia Midkhatovna Teletaeva , Tatyana Yurevna Semiglazova , Irina Aleksandrovna Baldueva

OF-2448

Joint Analysis of the Interferon Gene Signatures and Cancer-Testis Gene Expression in Cutaneous Melanoma Patients

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2448

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Ekaterina Prochorovna Kisseleva, Igor Vladimirovich Kudryavtsev, Artem Arkad’evich Rubinstein, Eleonora Aleksandrovna Starikova, Jennet Tumarovna Mammedova, Tatiana Leonidovna Nekhaeva, Aleksey Viktorovich Novik , Irina Alexandrovna Baldueva

OF-2436

Altered Peripheral Blood T-Helper Cell Maturation and Polarization in Primary Skin Melanoma

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2436

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Kseniya Yurievna Sinichenkova, Agnesa Vladimirovna Panferova, Ruslan Hudaverdievich Abasov, Nina Valerievna Gegeliya, Ilya Vladimirovich Sidorov, Anastasiya Sergeevna Sharlay, Dmitriy Michailovich Konovalov, Dmitriy Vitalievich Litvinov, Galina Anatolievna Novichkova, Alexandr Evgenievich Druy

OF-2223

Molecular and Clinical Characteristics of Sarcomas with BCOR Genetic Alteration in Children and Adolescents

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2223

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Elvira S. Lyubimskaya, Ekaterina Alexandrovna, Busko , Grigory Vladimirovich Zinovev , Vladimir Vladimirovich Shchukin , Anastasia Borisovna Goncharova , Ksenia Vyacheslavovna Kozubova , Pavel Yurievich Grishko , Liya Maratovna Saveleva , Roman Andreevich Kadyrleev , Elena Igorevna Busko , Anna Andreevna Cheminava , Ilya Alexandrovich Burovik , Sergey Sergeevich Bagnenko

OF-2443

Differential Diagnostics of Soft Tissue Sarcoma Recurrence and Postoperative Changes: A Comparative Efficacy of Contrast-Enhanced Ultrasound versus Magnetic Resonance Imaging

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2443

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Maksim Ivanovich Sluzhev, Vladislav Vladimirovich Semiglazov , Gulfija Midkhatovna Teletaeva, Aleksei Viktorovich Novik, Dilorom Khamidovna Latipova, Anna Igorevna Semenova, Elena Viktorovna Tkachenko, Sergei Valerevich Kondratev, Nadezhda Aleksandrovna Brish, Yuliya Vladimirovna Alekseeva, Tatyana Valerevna Sharonova, Konstantin Evgenevich Katsuba, Anastasia Valerevna Malek, Tatiana Yurievna Semiglazova

OF-2396

Plasmapheresis Combined with First-Line mFOLFOX-6 and Bevacizumab Therapy in Metastatic Colorectal Cancer

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2396

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ORIGINAL ARTICLES. B. EXPERIMENTAL RESEARCH

Olga Aleksandrovna Knyazeva, Elena Alfredovna Kireeva, Albina Ilyasovna Urazaeva, Sabina ILYASOVNA Urazaeva , IRINA GRIGOREVNA Konkina

OF-2226

Antistress and Antitumor Properties of 3D-metal Gluconates in a Stress Disorder Model in BALB/C Mice with Myeloma

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2226

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ORIGINAL ARTICLES. A. PROTOCOLS OF CLINICAL RESEARCH

Olga E. Lavrinovich , Andrey P. Karitsky , Yuliya A. Tatishcheva , Svetlana A. Kulyova

OF-2149

Fertility Preservation in Pre-Pubertal and Pubertal Cancer Female Patients

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2149

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Andrey P. Karitsky , Olga E. Lavrinovich , Julia A. Tatischeva , Svetlana A. Kulyova

OF-2148

Fertility Preservation in Pre-Pubertal and Pubertal Cancer Male Patients

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2148

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EXPERT OPINION

Кристина Вячеславовна Орлова, Игорь Вячеславович Самойленко, Наталия Николаевна Петенко, Валерия Витальевна Назарова, Али Мурадович Мудунов, Татьяна Юрьевна Семиглазова, Замира Ахмедовна Раджабова, Григорий Владимирович Зиновьев, Александр Александрович Феденко, Андрей Павлович Поляков, Людмила Григорьевна Жукова, Илья Анатольевич Покатаев, Игорь Аглямович Утяшев, Елена Александровна Гайсина, Владислав Владимирович Петкау, Рози Артемовна Терян, Лев Вадимович Демидов

OF-2413

Expert Consensus Statement: Sonidegib for the Treatment of Locally Advanced Basal Cell Carcinoma

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2413

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Tatiana Y. Kekeeva, Evgeny Imyanitov, Irina Demidova, Alexander Drui, Maxim Filipenko , Grigory Tsaur , Alexey Tsukanov

OF-2259

Molecular Diagnostics in Ovarian Cancer: Position Statement of the Interregional Organization of Molecular Geneticists in Oncology and Oncohematology

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2259

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EXPERIENCE OF ONCOLOGY CLINICS

Grigoriy Zinovev, Maria Gafton, Andrey Borodulin, Georgiy Gafton, Ivan Gafton, Mikhail Sinyachkin, Ekaterina Gneeva, Anzhelika Salimova

OF-2314

Vascular Reconstruction in Patients with Soft Tissue Sarcomas: Experience of N.N. Petrov National Medical Research Center of Oncology

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2314

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CLINICAL CASES

Olga Mikhailovna Romantsova, Ekaterina Evgenevna Zelenova, Khayale Asif qizi Aleskerova, Anastasiya Alekseevna Lovenger, Denis Borisovich Khestanov, Elena Vyacheslavovna Sharapova, Tatyana Sergeevna Belysheva, Elena Vladimirovna Mikhailova, Svetlana Rafaelevna Varfolomeeva

OF-2256

A Aggressive Dermatofibroma with Metastatic Lesions of the Lymph Nodes, Lungs, and Bones. Description of the Clinical Case. Literature Review

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2256

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REVIEWS

Juliya Nikolaevna Vinogradova, Daria Vasilevna Kozlova, Denis Vladimirovich Zaslavsky, Alexey Viktorovich Taganov, Nikolay Vasilevich Ilyin

OF-2254

Assessment Methods for Cutaneous Manifestations in Mycosis Fungoides

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2254

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Andrey D. Ermak, Denis V. Gavrilov, Roman E. Novitskiy, Alexander V. Gusev, Yuriy I. Komarov, Anna E. Andreychenko

OF-2258

Machine Learning for Cancer Risk Prediction Using Electronic Health Records: An Automated Screening Framework

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2258

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Anna D. Kosova, Polina G. Serbun, Petr P. Snetkov, Ekaterina S. Mironova, Svetlana N. Morozkina, Sofya M. Balazovskaya, Igor M. Kvetnoy

OF-2227

Small molecules as promising regulators of sorcin levels during oncogenesis

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2227

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Aleksandr Martianov, Grigoriy Yanus, Ekaterina Kuligina, Anna Portyanko, Aleksandr Togo, Evgeny Imyanitov

OF-1910

Circulating Tumor RNA-Based Liquid Biopsy for Primary Noninvasive Diagnosis of Pulmonary Adenocarcinoma

https://doi.org/10.37469/0507-3758-2025-71-4-OF-1910

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Vladimir Yuryevich Startsev, Gleb Valentinovich Kondratiev, Kirill Alexandrovich Maltsev

OF-2167

Metastatic Hormone-Sensitive Prostate Cancer: The Role of Docetaxel in Triple-Therapy Regimens

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2167

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Grigoriy Arkadjevich Yanus, Aglaya Gennadievna Iyevleva, Anastasia Nikolaevna Ershova, Darya Evgenijevna Martynenko, Ksenia Aleksandrovna Lipendina, Svetlana Nikolaevna Aleksakhina, Evgeny Naumovich Imyanitov

OF-2205

Microsatellite Instability and Total Tumor Mutational Burden as Markers of Immune Checkpoint Inhibitor Efficacy in Colorectal Cancer

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2205

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HISTORY OF ONCOLOGY

Zamira A-G. Radzhabova

OF-2383

The Evolution of Head and Neck Oncology: Commemorating the Centenary of Birth of Robert Ivanovich Wagner

https://doi.org/10.37469/0507-3758-2025-71-4-OF-2383

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The scientific and practical journal "VOPROSY ONKOLOGII" included in the list of leading peer-reviewed scientific publications of the Higher Attestation Commission of Russia (НАС), recommended for the publication of articles containing materials of candidate and doctoral dissertations. The publication is indexed by the Scopus, Russian Science Citation Index (RSCI) based on Web of Science.

The journal provides immediate open access to its content under the Diamond Open Access model, based on the following principle: free dissemination of academic knowledge among readers - publications are fully accessible to readers free of charge, and there are no publication fees. Full-text materials are available open access under the Creative Commons CC-BY.

The journal is registered with the Federal Service for Supervision of Communications, Information Technology and Mass Media (Roskomnadzor).

Certificate of registration of mass media - PI No. FS77 47156 of 3 November 2011.

ISSN 0507-3758 (Print)
ISSN 2949-4915 (Online)