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Abstract
The connection between circadian rhythms and cancer is bilateral at the body and cellular level. Negative impact of tumor development on circadian rhythms represents one of its aspects.
Materials and methods. 16 FVB/N and 16 FVB/N transgenic HER2/neu female mice were used in the experiment. 4 mice of each line were euthanized at ZT0 (light switch-on time), ZT6, ZT12 and ZT18. Bmal1, Clock and Cry1 gene expression was evaluated in the suprachiasmatic nucleus, liver, mammary tissue and tumors by real-time PCR. Content of BMAL1 and CLOCK proteins in mammary tissue and tumors was evaluated by immunohistochemistry.
Results. Absence of clock genes expression and clock proteins content daily oscillations was observed in spontaneous mammary adenocarcinomas of HER2/neu transgenic mice. We also revealed decrease in peak values of clock genes expression in the suprachiasmatic nucleus, liver and mammary gland in tumor- bearing animals.
Conclusions. The obtained data confirm the hypothesis about disruption of circadian rhythms in breast tumors and negative influence of tumors on the rhythms of the whole organism.
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